Studies on Surinamese medicinal plants with angiosuppressive characteristics
Aberrant angiogenesis is involved in a multitude of distinct diseases including cancer, rheumatoid arthritis and chronic wounds, as well as certain cardiovascular, ocular, and skin diseases. This has led to the development of a wide array of therapeutically efficacious anti- and pro-angiogenic substances, and the identification of a number of (plant-derived) substances that allegedly prevent angiogenesis-dependent diseases. Based on the latter consideration, Prof. Dr. Dennis Mans, Chair of Pharmacology, with special attention to plants with medicinal properties, has initiated a large-scale research project to evaluate Surinamese medicinal plants for their potential to interfere with angiogenesis.
From a panel of Surinamese medicinal plants, recent work in the lab identified Lantana Camara L. Verbenaceae with anti-angiogenic properties in human umbilical vein endothelial cells (HUVECs) and in a zebrafish model system. Significant inhibition of cell migration and proliferation was observed as well as zebrafish caudal fin regeneration and subintestinal vessel growth (Mans et al., Eur J Med Plants 2015). Current research focuses on elucidating the mechanism underlying these anti-angiogenic effects following Lantana Camara exposure. Ongoing projects also include characterizing chemical properties of Surinamese medicinal plants.
The program is carried out by the Departments of Pharmacology of the Faculty of Medical Sciences, Anton de Kom University of Suriname, and is funded by the Suriname Conservation Foundation.
- Mans DRA, Toelsie JR, Djotaroeno M, Friperson P, Pawirodihardjo J, Magali I, Soekhoe RC, Oedairadjsingh K, Hasrat JA, BipatR. Anti-angiogenic rather than pro-angiogenic and wound healing-promoting effects of Lantana camara L. (Verbenaceae) in a zebra fish model of tissue regeneration and in cultured human umbilical vein endothelial cells. Eur J Med Plants 9: 1-12, 2015 (Article no. EJMP.19330).
- Mans DRA. Blood, sweat, and tears. Angiogenesis, angiogenesis-dependent diseases, and angiogenesis-interfering therapies. Int Arch Med Vol 8 Vol. 8 No. 131 doi: 10.3823/1730.